Efficacy and safety of apixaban compared with aspirin in the elderly. New anticoagulants and the future of cardiology revista. Averroes apixaban versus asa to prevent stroke in af. In a doubleblind study, we randomly assigned 5599 patients with atrial fibrillation who were at increased risk for stroke and for whom. Comparison of study designs and key findings of the averroes and aristotle trials connolly et al. Find, read and cite all the research you need on researchgate. He is best known for his commentaries on aristotle. Installation of adobe acrobat pro dc trial by default uninstalls any earlier version of adobe acrobat on windows devices. However, many patients are not suitable candidates for or are unwilling to receive vitamin k. In a doubleblind study, we randomly assigned 5599 patients with atrial fibrillation who were at. Pdf efficacy and safety of apixaban compared with aspirin. Averroes article about averroes by the free dictionary. Apixaban to prevent stroke in patients with atrial fibrillation. Downloaded from at hospital sirio libanes on march 2, 2011.
Concerning the eternity of the world the first proof the second proof the third proof the fourth proof the second discussion. Apixabancalibrated antifxa activity in relation to outcome events. These lecture notes were created several years ago and have been only slightly modified recently. The design and main results of the averroes trial have been published 10, 11. The design, inclusion criteria, study execution, and main results of the averroes trial have been published.
Averroes abul walid mahommed ibn achmed, ibn mahommed ibn roschd, arabian philosopher, astronomer, and writer on jurisprudence. Pdf efficacy and safety of apixaban compared with aspirin in the. Averroes also argues that knowledge and power inevitably give rise to speech. Efficacy and safety of apixaban compared with aspirin in the. Download pdf the investigational factor xa inhibitor apixaban is superior to aspirin for the prevention of stroke in patients with atrial fibrillation af, and does not increase the risk of bleeding. Pfe today announced that the companies have agreed to stop the phase 3 averroes clinical trial of apixaban in patients with atrial fibrillation. Efficacy and safety of apixaban compared with aspirin in.
Pdf the effects of apixaban on hospitalizations in patients. Ibn roschd, or averroes, as he was called by the latins, was educated in his native city, where his father and grandfather had held the office of cadi judge in civil affairs. Apixaban in patients with atrial fibrillation nejm. This stimulating book covers all area of the twelfth century muslim philosophers life from his transmission of aristotelian thought to the western world. Averroes on the relationship between philosophy and. Apixaban is a novel oral direct factor xa inhibitor that. His life, work and influence great islamic writings majid fakhry on. Jul 04, 2007 bleeding during treatment with aspirin versus apixaban in patients with atrial fibrillation unsuitable for warfarin. A phase iii study of apixaban in patients with atrial fibrillation averroes the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Modification of outcomes with aspirin or apixaban in relation. This subgroup analysis suggests that the absolute benefit of apixaban over aspirin might be enhanced in secondary stroke prevention. Pdf the effects of apixaban on hospitalizations in. Backgroundvitamin k antagonists are highly effective in preventing stroke in patients with atrial fibrillation but have several limitations. This quiz and worksheet duo can help you assess your knowledge of ibn rushds life and works.
In this randomized, doubleblind trial, we compared apixaban at a dose of 5 mg twice daily with warfarin target international normalized ratio, 2. Averroes retained from the aristotles thought the following points. Mar 25, 2011 download pdf the investigational factor xa inhibitor apixaban is superior to aspirin for the prevention of stroke in patients with atrial fibrillation af, and does not increase the risk of bleeding. He was far more important and influential in jewish and christian thought than in islam. Averroes definition of averroes by the free dictionary. The 2011 apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin k antagonist treatment averroes trial randomized 5,599 patients with af thought to be unsuitable candidates for vka therapy to apixaban or aspirin. Jan garrett this page slightly revised december 4, 2007. In the islamic world, he played a decisive role in the defense of greek philosophy against the onslaughts of the as. Thus, a clear superiority of apixaban over aspirin was shown in terms of efficacy, with comparable safety. Averroes was a doubleblind trial including 5599 patients from 36 countries who were at increased risk for stroke because of the presence of at least 1 risk factor in addition to atrial. Project muse an evaluation of averroes paraphrase on. The myth of the framework in borgess averroes search 151 logical narrative encourages ways of human behaviour while discouraging others.
Scribd is the worlds largest social reading and publishing site. A previous history of stroke increases the annual risk of stroke from 45% to 117% in patients with nonvalvular atrial fibrillation. The refutation of their theory of the incorruptibility of. Averroes definition of averroes by medical dictionary. We compared the baseline characteristics and effects of apixaban compared with aspirin on clinical outcomes by age. A conditional hierarchy nauman faizi university of virginia introduction this essay is an attempt to study the manner in which averroes constructs the. Averroes apixaban versus asa to prevent stroke in af patients who have failed or are unsuitable for vitamin k antagonist treatment trial n 5,599 included 1,898 patients. Pdf the aim of this study was to evaluate the effects of apixaban, a novel oral factor xa inhibitor, on the need for cardiovascular. Ibn rushd averroes is regarded by many as the foremost islamic philosopher. An evaluation of averroes paraphrase on aristotles poetics introduction it seems that aristotles poetics is a work which looms in the consciousness of critics of every age, and notably from the latter half of the sixteenth century onwards as critics become better practiced in their profession, they either consult this work or start to.
Averroes is a doubleblind, doubledummy superiority trial of apixaban 5 mg twice daily 2. Acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin k antagonist treatment was a randomized doubleblind clinical trial which tested the efficacy and safety of apixaban, a new factor xa inhibitor, against aspirin for prevention of thromboembolism in af. Bleeding during treatment with aspirin versus apixaban in. This page is not for direct citation in scholarly work. A conditional hierarchy nauman faizi university of virginia introduction this essay is an attempt. Abulwalid ibn rushd, better known as averroes 11261198, stands out as a towering figure in the history of arabislamic thought, as well as that of westeuropean philosophy and theology. If you choose to retain the existing acrobat xi on your machine, you need to change the default by unchecking the remove earlier version option in acrobat downloader ui.
Therefore, zur linde must repress feelings such as mercy or compassion, and nourish, instead, violence, murder, and destruction. Ibn rushd averroes internet encyclopedia of philosophy. Apixaban triumphs over aspirin for stroke prevention in. Ibn rushd averroes 11261198 abu alwalid muhammad ibn ahmad ibn rushd, better known in the latin west as averroes, lived during a unique period in western intellectual history, in which interest in philosophy and theology was waning in the muslim world and just beginning to flourish in latin christendom. The study will be stopped early because a predefined interim analysis by the independent data monitoring committee dmc revealed clear evidence of a.
Averroes nct00496769 was a randomised, doubleblind, doubledummy study to assess the superiority of apixaban 5 mg bid vs aspirin. The averroes study was sponsored by bristolmyers squibb and pfizer. Averroes apixaban versus asa to prevent stroke in af patients who. Background vitamin k antagonists have been shown to prevent stroke in patients with atrial fibrillation. The incoherence of the incoherence averroes ibn rushd etext conversion muhammad hozien. The rationale, design, definitions of outcomes, and main results of the averroes trial clinicaltrials. A phase iii study of apixaban in patients with atrial. Pdf apixaban in patients with atrial fibrillation researchgate. Age and ageing oxford academic journals oxford university press. The translations of the greek writings were normally accompanied by many greek and arabic commentaries.
The averroes trial 10 showed the superior efficacy of apixaban over aspirin without a significant increase in major bleeding complications in patients with atrial fibrillation. Aristotle nct00412984 is a doubleblind, doubledummy, event driven phase iii trial testing noninferiority of apixaban 5 mg twice daily versus warfarin. In brief, averroes was a prospective, multicentre, randomised trial of 5,599 patients with af conducted at 522 centres in 36 countries comparing apixaban with aspirin. He wrote commentaries on plato and aristotle and defended philosophical study of religion against theologians such as alghazali, who had attacked muslim philosophers avicenna and alfarabi. Power can be inferred by gods ability to bring creations into existence. In a doubleblind study, we randomly assigned 5599 patients with atrial fibrillation. Commentaries by alexander of aphrodisias and by simplicius were frequent, but those by the arab averroes on the aristotelian works were ultimately the most influential. Download fulltext pdf efficacy and safety of apixaban compared with aspirin in the elderly. We will here briefly discuss the clinical implications of the trial. Averroes on the relationship between philosophy and scripture. The averroes study has shown that apixaban was clearly superior to.
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